Manchester United - Southampton
Onderstaand een overzicht van de gespeelde wedstrijden tussen Manchester United en Southampton
| 28 november 2020 |  Premier League | Southampton - Manchester United | |
| 25 april 2020 | Premier League | Manchester United - Southampton | |
| 31 augustus 2019 | Premier League | Southampton - Manchester United | 1-1 |
| 02 maart 2019 | Premier League | Manchester United - Southampton | 3-2 |
| 01 december 2018 | Premier League | Southampton - Manchester United | 2-2 |
| 30 december 2017 | Premier League | Manchester United - Southampton | 0-0 |
| 23 september 2017 | Premier League | Southampton - Manchester United | 0-1 |
| 19 augustus 2016 | Premier League | Manchester United - Southampton | 2-0 |